Publication
530
Tetrahedron
Lett., 42 (17), 3077-3080, 2001
DOI: 10.1016/S0040-4039(01)00388-4 |
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Synthesis and electron-transfer reactions of some 3-difluoroacetylated
imidazo[1,2- ]pyridine derivatives
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Conrad Burkholder, William R. Dolbier, Jr., Maurice Médebielle
and Samia Ait-Mohand
University of Florida, Department
of Chemistry, PO Box 117200, Gainesville, FL 32611-7200, USA and Université Denis
Diderot-Paris 7, Laboratoire d'Electrochimie Moléculaire, UMR CNRS 7591, 2 Place
Jussieu, Case courrier 7107, 75251, Paris Cedex 05, France
The synthesis of new 3-chlorodifluoroacetylated
imidazo[1,2-a ]pyridines
and their difluoroacetyl derivatives is presented.
The reductive cleavage of the halogenated ketones
was investigated by cyclic voltammetry, and
tetrakis(dimethylamino)ethylene (TDAE) was found
to be an effective reductant for the generation
of the corresponding  ,-difluoroacetyl anions and for the synthesis of new
gem-difluoromethylated imidazo[1,2-a]pyridine derivatives. |
