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Laboratoire d'Electrochimie Moleculaire, LEM, Paris

UMR CNRS - Université Paris Diderot - Paris France
   
 
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Université Paris Diderot
Université de Paris CNRS, Centre National de la Recherche Scientifique 		 
 


Le LEM - Publications: Abstracts

Publication 533

Tetrahedron Lett., 42 (20), 3459-3462, 2001
DOI: 10.1016/S0040-4039(01)00513-5 		 

 

Synthesis of -(heteroarylthio)- , -difluoroacetophenone derivatives via the SRN1 methodology

C. Burkholder, W. R. Dolbier, Jr., M. Médebielle and S. Ait-Mohand

University of Florida, Department of Chemistry, PO Box 117200, Gainesville, FL 32611-7200, USA Université Denis Diderot-Paris 7, Laboratoire d'Electrochimie Moléculaire, UMR CNRS 7591, 2 Place Jussieu, F-75251, Paris Cedex 05, France


New small alpha, Greek-(heteroarylthio)-small alpha, Greek,small alpha, Greek-difluoroacetophenone Ar1-COCF2S-Ar2 derivatives were synthesized in moderate to good yields via the SRN1 methodology, from the reaction of a series of chlorodifluoromethylated ketones with aromatic and heterocyclic thiols. The corresponding Ar1-CHOHCF2S-Ar2 were also prepared in moderate yields, using sodium borohydride in absolute ethanol. The compounds may find some biological applications as potent anti-HIV-1 as well as useful synthons for agrochemicals.
 
   
 
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