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Laboratoire d'Electrochimie Moleculaire, LEM, Paris

UMR CNRS - Université Paris Diderot - Paris France

Master Frontiers in Chemistry | UFR de Chimie - Université Paris Diderot - Paris 7 CNRS - Institut de chimie Université de Paris Master Chimie Sorbonne Paris Cité UFR de Chimie - Université Paris Diderot - Paris 7 CNRS - Institut de chimie
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Université Paris Diderot
Université de Paris CNRS, Centre National de la Recherche Scientifique

Le LEM - Publications: Abstracts

Publication 535

J. Am. Chem. Soc., 123 (20), 4817 -4825, 2001
DOI: 10.1021/ja004050f S0002-7863(00)04050-6


Elastic Bounded Diffusion and Electron Propagation: Dynamics of the Wiring of a Self-Assembly of Immunoglobulins Bearing Terminally Attached Ferrocene Poly(ethylene glycol) Chains According to a Spatially Controlled Organization

Agnès Anne, Christophe Demaille, and Jacques Moiroux

Contribution from the Laboratoire d'Electrochimie Moléculaire, Unité Mixte de Recherche Université - CNRS No 7591, Université de Paris 7 - Denis Diderot, 2 place Jussieu, 75251 Paris Cedex 05, France

Molecular monolayers of immunoglobulins bearing terminally attached ferrocene poly(ethylene glycol) chains (IgG-PEG-Fc) were self-assembled at an electrode surface in a step-by-step manner involving antigen-antibody recognition reactions. The total number N of assembled IgG-PEG-Fc monolayers and the number of spacers ni separating two successive IgG-PEG-Fc monolayers were controlled and varied. Electron transport through the protein assembly involves the dynamics of the terminally attached PEG chains and isotopic electron exchange between ferrocene heads belonging to successive IgG-PEG-Fc monolayers. The model of elastic bounded diffusion enabled us to analyze quantitatively the dependence of the rate of electron transport on N, ni, and the rate constant (ke) of isotopic electron exchange. Wiring of a molecular monolayer of redox enzyme is also quantitatively characterized.

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