Publication
537
Tetrahedron
Lett ., 42 (29), 4811-4814, 2001
DOI: 10.1016/S0040-4039(01)00873-5 |
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Single electron transfer approaches to the practical synthesis of aromatic
and heterocyclic-CF2H derivatives
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William R. Dolbier, Jr.,
Maurice Médebielle and Samia Ait-Mohand
University of Florida, Department
of Chemistry, PO Box 117200, Gainesville, FL 32611-7200, USA Université Denis Diderot-Paris 7, Laboratoire
d'Electrochimie Moléculaire, UMR CNRS 7591, 2 Place Jussieu, F-75251, Paris
Cedex 05, France
Single electron transfer (SET) approaches with organic reductants such as
sodium hydroxymethanesulfinate (Rongalite®), sodium dithionite (regarded as
precursors of sulfoxylate radical anion) and tetrakis(dimethylamino)ethylene
(TDAE) were employed for the reductive dehalogenation of a series of
halogeno-difluoromethylated aromatics and heterocycles, and for the practical
synthesis of the corresponding difluoromethylated derivatives. |
