Publication
560
J. Org.
Chem., 67 (24), 8513 -8518, 2002
DOI: 10.1021/jo025880+ S0022-3263(02)05880-2 |
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Surface-Modified Carbon Felts: Possible Supports for Combinatorial
Chemistry
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Estelle
Coulon and Jean Pinson
Contribution from the Centre de Recherche
de Vitry, Aventis Pharma, 13 Quai Jules Guesdes,
BP14, 94403 Vitry sur Seine Cedex, France and the
Laboratoire d'Electrochimie Moléculaire, Université de
Paris 7 - Denis Diderot, Case Courrier 7107, 2 place
Jussieu, 75251 Paris Cedex 05, France
It is possible to prepare carbon-based analogues of the Merrifield resin
by electrochemical reduction of diazonium salts or oxidation of aryl
acetates on high specific surface area carbon felts. These modified felts
can undergo further reactions: nucleophilic substitution, Suzuki reaction,
and finally reductive electrochemical cleavage, taking advantage of the
conductivity of the carbon felt. This provides a simple example of the
possible use of electrochemistry in combinatorial synthesis. |
