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Laboratoire d'Electrochimie Moleculaire, LEM, Paris

UMR CNRS - Université Paris Diderot - Paris France

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Université Paris Diderot
Université de Paris CNRS, Centre National de la Recherche Scientifique

Le LEM - Publications: Abstracts

Publication 564

J. Am. Chem. Soc., 125 (5), 1112 -1113, 2003
DOI: 10.1021/ja028640k S0002-7863(02)08640-7


3'-Ferrocene-Labeled Oligonucleotide Chains End-Tethered to Gold Electrode Surfaces: Novel Model Systems for Exploring Flexibility of Short DNA Using Cyclic Voltammetry

Agnès Anne, Agnès Bouchardon and Jacques Moiroux

Contribution from the Laboratoire d'Electrochimie Moléculaire, Université de Paris 7 - Denis Diderot, Case Courrier 7107, 2 place Jussieu, 75251 Paris Cedex 05, France. E-mail:

The flexibility of DNA is of central importance in biology, medicine, materials science, and mechanical engineering. In this study, we report an unprecedented electrochemical approach for investigating the flexibility of a short (typically 20-base), surface end-tethered single-stranded synthetic DNA oligonucleotide and of its postformed DNA duplex, taking as an example the homopolymer (dT)20 sequence in the regime of very high ionic strength (~1 M).
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