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Publication 564
J. Am.
Chem. Soc., 125 (5), 1112 -1113, 2003
DOI: 10.1021/ja028640k S0002-7863(02)08640-7 |
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3'-Ferrocene-Labeled Oligonucleotide Chains End-Tethered to
Gold Electrode Surfaces: Novel Model Systems for Exploring
Flexibility of Short DNA Using Cyclic Voltammetry
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Agnès
Anne, Agnès Bouchardon and Jacques Moiroux
Contribution from the Laboratoire d'Electrochimie
Moléculaire, Université de Paris 7 -
Denis Diderot, Case Courrier 7107, 2 place Jussieu,
75251 Paris Cedex 05, France. E-mail: anne@paris7.jussieu.fr
The flexibility of DNA is of central importance in biology, medicine,
materials science, and mechanical engineering. In this study, we report
an unprecedented electrochemical approach for investigating the flexibility
of a short (typically 20-base), surface end-tethered single-stranded
synthetic DNA oligonucleotide and of its postformed DNA duplex, taking
as an example the homopolymer (dT)20 sequence in the regime
of very high ionic strength (~1 M). |
