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Laboratoire d'Electrochimie Moleculaire, LEM, Paris

UMR CNRS - Université Paris Diderot - Paris France

   
 
Master Frontiers in Chemistry | UFR de Chimie - Université Paris Diderot - Paris 7 CNRS - Institut de chimie Université de Paris Master Chimie Sorbonne Paris Cité UFR de Chimie - Université Paris Diderot - Paris 7 CNRS - Institut de chimie
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Université Paris Diderot
Université de Paris CNRS, Centre National de la Recherche Scientifique
 
 


Le LEM - Publications: Abstracts

Publication 635

Chem. Eur. J. 14, 7186-7192, 2008.
DOI: 10.1002/chem.200800368
 

DNA Damage and Radical Reactions: Mechanistic Aspects, Formation in Cells and Repair Studies

Véronique Balland , Christelle Hureau , Angela Maria Cusano , Yingli Liu , Thierry Tron, Benoît Limoges

Laboratoire de Thermodynamique et Interactions Moléculaires, Université Blaise Pascal, Aubière, France, and BiosCiences, Institut Sciences Moléculaires Marseille (ISM2), UMR CNRS 6263, Aix-Marseille Université Centre Scientifique Saint Jérôme, 13397 Marseille Cedex 20, France

 


The formation of a dense monolayer of histidine-tagged recombinant laccase on gold electrodes by using a short thiol-NTA linker is described, as well as a kinetic analysis of the process by cyclic voltammetry. From a detailed analysis of the catalytic reduction of dioxygen by laccase in the presence of a one-electron redox mediator it can be concluded that the immobilized enzyme remains as active as in homogeneous solution.

 
   
 
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