Publication
844
J. Org. Chem., 82 (21), 11464-11473, 2017
DOI:10.1021/acs.joc.7b01991
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Mechanistic Insight into the Cu-Catalyzed C-S Cross-Coupling of Thioacetate with Aryl Halides. A Joint Experimental-Computational Study
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Silvia M. Soria-Castro, Diego M. Andrada, Daniel A. Caminos, Juan E. Argúello, Marc Robert, and Alicia B. Peñeñory
Departamento de Química Orgánica, Facultad de Ciencias Químicas, INFIQC, Universidad Nacional de Córdoba, CONICET, X5000HUA Córdoba, Argentina
Philipps-Universität Marburg, Fachbereich Chemie, Hans-Meerwein straße 4, 35032 Marburg, Germany
Krupp-Professur für Allgemeine und Anorganische Chemie, Universität des Saarlandes, 66123 Saarbrücken, Germany
Laboratoire d’Electrochimie Moléculaire, UMR 7591 CNRS, Université Paris Diderot, Sorbonne Paris Cité, 15 rue Jean-Antoine de Baïf, F-75205 Paris Cedex 13, France
The mechanism of the Ullmann-type reaction between potassium thioacetate (KSAc) and iodobenzene (PhI) catalyzed by CuI associated with 1,10-phenanthroline (phen) as a ligand was explored experimentally and computationally. The study on C–S bond formation was investigated by UV–visible spectrophotometry, cyclic voltammetry, mass spectrometry, and products assessment from radical probes. The results indicate that under experimental conditions the catalytically active species is [Cu(phen)(SAc)] regardless of the copper source. An examination of the aryl halide activation mechanism using radical probes was undertaken. No evidence of the presence of radical species was found during the reaction process, which is consistent with an oxidative addition cross-coupling pathway. The different reaction pathways leading to the experimentally observed reaction products were studied by DFT calculation. The oxidative addition–reductive elimination mechanism via an unstable CuIII intermediate is energetically more feasible than other possible mechanisms such as single electron transfer, halogen atom transfer, and sigma-bond methatesis. |
